Ontology highlight
ABSTRACT:
SUBMITTER: Huang ZL
PROVIDER: S-EPMC3926824 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Huang Zheng-Lan ZL Gao Miao M Li Qian-Yin QY Tao Kun K Xiao Qing Q Cao Wei-Xi WX Feng Wen-Li WL
Oncotarget 20131201 12
The chimeric Bcr-Abl oncoprotein, which causes chronic myeloid leukemia, mainly localizes in the cytoplasm, and loses its ability to transform cells after moving into the nucleus. Here we report a new strategy to convert Bcr-Abl to be an apoptotic inducer by altering its subcellular localization. We show that a rapalog nuclear transport system (RNTS) containing six nuclear localization signals directs Bcr-Abl into the nucleus and that nuclear entrapped Bcr-Abl induces apoptosis and inhibits prol ...[more]