Ontology highlight
ABSTRACT:
SUBMITTER: Shinsato Y
PROVIDER: S-EPMC3926825 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Shinsato Yoshinari Y Furukawa Tatsuhiko T Yunoue Shunji S Yonezawa Hajime H Minami Kentarou K Nishizawa Yukihiko Y Ikeda Ryuji R Kawahara Kohichi K Yamamoto Masatatsu M Hirano Hirofumi H Tokimura Hiroshi H Arita Kazunori K
Oncotarget 20131201 12
Although there is a relationship between DNA repair deficiency and temozolomide (TMZ) resistance in glioblastoma (GBM), it remains unclear which molecule is associated with GBM recurrence. We isolated three TMZ-resistant human GBM cell lines and examined the expression of O6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair (MMR) components. We used immunohistochemical analysis to compare MutL homolog 1 (MLH1), postmeiotic segregation increased 2 (PMS2) and MGMT expression in primar ...[more]