Targeting metabolic scavenging in pancreatic cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Lyssiotis CA
PROVIDER: S-EPMC3930347 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Publications
Targeting metabolic scavenging in pancreatic cancer.
Lyssiotis Costas A CA Cantley Lewis C LC
Clinical cancer research : an official journal of the American Association for Cancer Research 20131028 1
Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth. ...[more]
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