Ontology highlight
ABSTRACT:
SUBMITTER: Lou YW
PROVIDER: S-EPMC3932869 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Lou Yi-Wei YW Wang Pao-Yuan PY Yeh Shih-Chi SC Chuang Po-Kai PK Li Shiou-Ting ST Wu Chung-Yi CY Khoo Kay-Hooi KH Hsiao Michael M Hsu Tsui-Ling TL Wong Chi-Huey CH
Proceedings of the National Academy of Sciences of the United States of America 20140203 7
Glioblastoma multiforme (GBM), the grade IV astrocytoma, is the most common and aggressive brain tumor in adults. Despite advances in medical management, the survival rate of GBM patients remains poor, suggesting that identification of GBM-specific targets for therapeutic development is urgently needed. Analysis of several glycan antigens on GBM cell lines revealed that eight of 11 GBM cell lines are positive for stage-specific embryonic antigen-4 (SSEA-4), and immunohistochemical staining confi ...[more]