Ontology highlight
ABSTRACT:
SUBMITTER: Nogueira V
PROVIDER: S-EPMC3933310 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Nogueira Veronique V Hay Nissim N
Clinical cancer research : an official journal of the American Association for Cancer Research 20130529 16
Reactive oxygen species (ROS) are important in regulating normal cellular processes, but deregulated ROS contribute to the development of various human diseases, including cancers. Cancer cells have increased ROS levels compared with normal cells, because of their accelerated metabolism. The high ROS levels in cancer cells, which distinguish them from normal cells, could be protumorigenic, but are also their Achilles' heel. The high ROS content in cancer cells renders them more susceptible to ox ...[more]