Ontology highlight
ABSTRACT:
SUBMITTER: Uren AG
PROVIDER: S-EPMC39390 | biostudies-other | 1996 May
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19960501 10
Baculovirus inhibitors of apoptosis (IAPs) act in insect cells to prevent cell death. Here we describe three mammalian homologs of IAP, MIHA, MIHB, and MIHC, and a Drosophila IAP homolog, DIHA. Each protein bears three baculovirus IAP repeats and an N-terminal ring finger motif. Apoptosis mediated by interleukin 1beta converting enzyme (ICE), which can be inhibited by Orgyia pseudotsugata nuclear polyhedrosis virus IAP (OpIAP) and cowpox virus crmA, was also inhibited by MIHA and MIHB. As MIHB a ...[more]