Ontology highlight
ABSTRACT:
SUBMITTER: Mukherjee S
PROVIDER: S-EPMC3946958 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Mukherjee Sumanta S Rasky Andrew J AJ Lundy Phil A PA Kittan Nicolai A NA Kunkel Steven L SL Maillard Ivan P IP Kowalski Paul E PE Kousis Philaretos C PC Guidos Cynthia J CJ Lukacs Nicholas W NW
Journal of immunology (Baltimore, Md. : 1950) 20131223 3
Notch activation plays an important role in T cell development and mature T cell differentiation. In this study, we investigated the role of Notch activation in a mouse model of respiratory syncytial virus (RSV)-exacerbated allergic airway disease. During RSV exacerbation, in vivo neutralization of a specific Notch ligand, Delta-like ligand (Dll)-4, significantly decreased airway hyperreactivity, mucus production, and Th2 cytokines. Lunatic Fringe (Lfng), a glycosyltransferase that enhances Notc ...[more]