Ontology highlight
ABSTRACT:
SUBMITTER: Steinmeyer K
PROVIDER: S-EPMC394869 | biostudies-other | 1994 Feb
REPOSITORIES: biostudies-other
Steinmeyer K K Lorenz C C Pusch M M Koch M C MC Jentsch T J TJ
The EMBO journal 19940201 4
Voltage-gated ClC chloride channels play important roles in cell volume regulation, control of muscle excitability, and probably transepithelial transport. ClC channels can be functionally expressed without other subunits, but it is unknown whether they function as monomers. We now exploit the properties of human mutations in the muscle chloride channel, ClC-1, to explore its multimeric structure. This is based on analysis of the dominant negative effects of ClC-1 mutations causing myotonia cong ...[more]