Ontology highlight
ABSTRACT:
SUBMITTER: Humbert S
PROVIDER: S-EPMC395104 | biostudies-other | 1994 May
REPOSITORIES: biostudies-other
Humbert S S van Vuuren H H Lutz Y Y Hoeijmakers J H JH Egly J M JM Moncollin V V
The EMBO journal 19940501 10
The human BTF2 (TFIIH) transcription factor is a multisubunit protein involved in transcription initiation by RNA polymerase II (B) as well as in DNA repair. In addition to the previously characterized p62 and p89/ERCC3 subunits, we have cloned two other subunits of BTF2, p44 and p34. The gene encoding p44 appeared to be the human counterpart of SSL1, a gene involved in translation and UV resistance in yeast. Interestingly, the p34 subunit also has homology with a domain of SSL1, suggesting that ...[more]