Gene co-expression network analysis reveals common system-level properties of prognostic genes across cancer types.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC3951205 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Publications
Gene co-expression network analysis reveals common system-level properties of prognostic genes across cancer types.
Yang Yang Y Han Leng L Yuan Yuan Y Li Jun J Hei Nainan N Liang Han H
Nature communications 20140101
Prognostic genes are key molecules informative for cancer prognosis and treatment. Previous studies have focused on the properties of individual prognostic genes, but have lacked a global view of their system-level properties. Here we examined their properties in gene co-expression networks for four cancer types using data from 'The Cancer Genome Atlas'. We found that prognostic mRNA genes tend not to be hub genes (genes with an extremely high connectivity), and this pattern is unique to the cor ...[more]
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