Ontology highlight
ABSTRACT:
SUBMITTER: Awadalla M
PROVIDER: S-EPMC3954455 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Awadalla Maged M Miyawaki Shinjiro S Abou Alaiwa Mahmoud H MH Adam Ryan J RJ Bouzek Drake C DC Michalski Andrew S AS Fuld Matthew K MK Reynolds Karen J KJ Hoffman Eric A EA Lin Ching-Long CL Stoltz David A DA
Annals of biomedical engineering 20131206 4
The pathogenesis of cystic fibrosis (CF) airway disease is not well understood. A porcine CF model was recently generated, and these animals develop lung disease similar to humans with CF. At birth, before infection and inflammation, CF pigs have airways that are irregularly shaped and have a reduced caliber compared to non-CF pigs. We hypothesized that these airway structural abnormalities affect airflow patterns and particle distribution. To test this hypothesis we used computational fluid dyn ...[more]