Ontology highlight
ABSTRACT:
SUBMITTER: Chapagain A
PROVIDER: S-EPMC3956172 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Chapagain Ananda A Caton Paul W PW Kieswich Julius J Andrikopoulos Petros P Nayuni Nanda N Long Jamie H JH Harwood Steven M SM Webster Scott P SP Raftery Martin J MJ Thiemermann Christoph C Walker Brian R BR Seckl Jonathan R JR Corder Roger R Yaqoob Muhammad Magdi MM
Proceedings of the National Academy of Sciences of the United States of America 20140225 10
Insulin resistance and associated metabolic sequelae are common in chronic kidney disease (CKD) and are positively and independently associated with increased cardiovascular mortality. However, the pathogenesis has yet to be fully elucidated. 11β-Hydroxysteroid dehydrogenase type 1 (11βHSD1) catalyzes intracellular regeneration of active glucocorticoids, promoting insulin resistance in liver and other metabolic tissues. Using two experimental rat models of CKD (subtotal nephrectomy and adenine d ...[more]