Unknown

Dataset Information

0

Effect of prenatal hypoxia in transgenic mouse models of preeclampsia and fetal growth restriction.

ABSTRACT: Mice lacking endothelial nitric oxide synthase (eNOS(-)(/-)) or catechol-O-methyl transferase (COMT(-/-)) exhibit a preeclampsia-like phenotype and fetal growth restriction. We hypothesized that a hypoxic insult would result in a more severe phenotype. Pregnant eNOS(-/-), COMT(-/-) and control (C57BL/6J) mice were randomized to hypoxic (10.5% O(2)) or normal conditions (20.9% O(2)) from gestational day 10.5 to 18.5. Hypoxia increased the blood pressure in all genotypes and proteinuria in C57BL/6J and eNOS(-/-) mice. Fetal survival was significantly reduced following hypoxia, particularly in eNOS(-/-) mice. Birth weight was decreased in both C57BL/6J and COMT(-/-) mice. Placentas from COMT(-/-) mice demonstrated increased peroxynitrite. Despite similar hypoxia-induced effects on maternal blood pressure and proteinuria, eNOS(-/-) embryos have a decreased tolerance to hypoxia. Compared to C57BL/6J, COMT(-/-) mice exhibited less severe changes in proteinuria and fetal growth when exposed to prenatal hypoxia. This relative resistance to prenatal hypoxia was associated with a significant increase in placental levels of peroxynitrite.

SUBMITTER: Rueda-Clausen CF 

PROVIDER: S-EPMC3960835 | biostudies-other | 2014 Apr

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Effect of prenatal hypoxia in transgenic mouse models of preeclampsia and fetal growth restriction.

Rueda-Clausen C F CF   Stanley J L JL   Thambiraj D F DF   Poudel R R   Davidge S T ST   Baker P N PN  

Reproductive sciences (Thousand Oaks, Calif.) 20130930 4

Mice lacking endothelial nitric oxide synthase (eNOS(-)(/-)) or catechol-O-methyl transferase (COMT(-/-)) exhibit a preeclampsia-like phenotype and fetal growth restriction. We hypothesized that a hypoxic insult would result in a more severe phenotype. Pregnant eNOS(-/-), COMT(-/-) and control (C57BL/6J) mice were randomized to hypoxic (10.5% O(2)) or normal conditions (20.9% O(2)) from gestational day 10.5 to 18.5. Hypoxia increased the blood pressure in all genotypes and proteinuria in C57BL/6  ...[more]

Similar Datasets

Unknown Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction.
| S-EPMC9495588 | biostudies-literature
Unknown Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia.
| S-EPMC6124516 | biostudies-literature
Unknown Sildenafil Therapy Normalizes the Aberrant Metabolomic Profile in the Comt(-/-) Mouse Model of Preeclampsia/Fetal Growth Restriction.
| S-EPMC4678899 | biostudies-literature
Unknown Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction.
| S-EPMC8277896 | biostudies-literature
Unknown Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions.
| S-EPMC6338749 | biostudies-literature
Unknown Proteomic analysis of the umbilical cord in fetal growth restriction and preeclampsia.
| S-EPMC8880394 | biostudies-literature
Unknown Early fetal hypoxia leads to growth restriction and myocardial thinning.
| S-EPMC2519936 | biostudies-literature
Unknown Trophoblast-Specific Expression of Hif-1? Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction.
| S-EPMC6391498 | biostudies-literature
Unknown Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction.
| S-EPMC7485876 | biostudies-literature
Unknown Proteomic Analysis of Maternal Urine for the Early Detection of Preeclampsia and Fetal Growth Restriction.
| S-EPMC8537852 | biostudies-literature