High-frequency nasal ventilation for 21 d maintains gas exchange with lower respiratory pressures and promotes alveolarization in preterm lambs.
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ABSTRACT:
SUBMITTER: Null DM
PROVIDER: S-EPMC3961520 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Publications
High-frequency nasal ventilation for 21 d maintains gas exchange with lower respiratory pressures and promotes alveolarization in preterm lambs.
Null Donald M DM Alvord Jeremy J Leavitt Wendy W Wint Albert A Dahl Mar Janna MJ Presson Angela P AP Lane Robert H RH DiGeronimo Robert J RJ Yoder Bradley A BA Albertine Kurt H KH
Pediatric research 20131230 4
<h4>Background</h4>Short-term high-frequency nasal ventilation (HFNV) of preterm neonates provides acceptable gas exchange compared to endotracheal intubation and intermittent mandatory ventilation (IMV). Whether long-term HFNV will provide acceptable gas exchange is unknown. We hypothesized that HFNV for up to 21 d would lead to acceptable gas exchange at lower inspired oxygen (O2) levels and airway pressures compared to intubation and IMV.<h4>Methods</h4>Preterm lambs were exposed to antenatal ...[more]
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