Ontology highlight
ABSTRACT:
SUBMITTER: Florczyk U
PROVIDER: S-EPMC3961841 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Florczyk Urszula U Jazwa Agnieszka A Maleszewska Monika M Mendel Mateusz M Szade Krzysztof K Kozakowska Magdalena M Grochot-Przeczek Anna A Viscardi Monika M Czauderna Szymon S Bukowska-Strakova Karolina K Kotlinowski Jerzy J Jozkowicz Alicja A Loboda Agnieszka A Dulak Jozef J
Antioxidants & redox signaling 20131218 11
<h4>Aims</h4>Nuclear factor E2-related factor 2 (Nrf2), a key cytoprotective transcription factor, regulates also proangiogenic mediators, interleukin-8 and heme oxygenase-1 (HO-1). However, hitherto its role in blood vessel formation was modestly examined. Particularly, although Nrf2 was shown to affect hematopoietic stem cells, it was not tested in bone marrow-derived proangiogenic cells (PACs). Here we investigated angiogenic properties of Nrf2 in PACs, endothelial cells, and inflammation-rel ...[more]