Ontology highlight
ABSTRACT:
SUBMITTER: Gelfand IM
PROVIDER: S-EPMC39670 | biostudies-other | 1996 Apr
REPOSITORIES: biostudies-other
Gelfand I M IM Kister A E AE Leshchiner D D
Proceedings of the National Academy of Sciences of the United States of America 19960401 8
A new approach of comparing protein structures that does not involve the procedure of superposition is suggested. An invariant system of coordinates for immunoglobulin molecules that is based on the geometrical symmetry inherent to the variable domain light-chain (VL)-heavy-chain (VH) complex is described. The coordinates of the Calpha atoms in 22 immunoglobulin structures are calculated in the invariant system of coordinates. We found that 76 identical positions in this Calpha framework are sym ...[more]