MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasma.
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ABSTRACT:
SUBMITTER: Bekris LM
PROVIDER: S-EPMC3967870 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Publications
MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasma.
Bekris Lynn M LM Lutz Franziska F Montine Thomas J TJ Yu Chang En CE Tsuang Debby D Peskind Elaine R ER Leverenz James B JB
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20130703 5
MicroRNA (miRNA) may be potential biomarkers of Alzheimer's disease (AD). The objective of this investigation was to demonstrate that miRNAs in human brain or biofluids are differentially expressed according to disease status, tissue type, neuritic plaque score or Braak stage. Post-mortem brain (PMB) miRNA were profiled using arrays and validated using quantitative RT-PCR (qRT-PCR). Five qRT-PCR-validated miRNAs were measured in an independent sample of PMB, cerebrospinal fluid and plasma from t ...[more]
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