Ontology highlight
ABSTRACT:
SUBMITTER: Singbrant S
PROVIDER: S-EPMC3971074 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Singbrant Sofie S Wall Meaghan M Moody Jennifer J Karlsson Göran G Chalk Alistair M AM Liddicoat Brian B Russell Megan R MR Walkley Carl R CR Karlsson Stefan S
Haematologica 20140110 4
The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compartments, and a marked enhancement of myeloid differentiation at the expense of other lineages. Accord ...[more]