Ontology highlight
ABSTRACT:
SUBMITTER: Brunck ME
PROVIDER: S-EPMC3973713 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Brunck Marion E G ME Nielsen Lars K LK
Stem cells translational medicine 20140305 4
High-dose chemotherapy is accompanied by an obligate period of neutropenia. Resulting bacterial and fungal infections are the leading cause of morbidity and mortality in neutropenic patients despite prophylactic antimicrobials and hematopoietic growth factor supplements. Replacing neutrophils in the patient through transfusion of donor cells is a logical solution to prevent fulminant infections. In the past, this strategy has been hampered by poor yield, inability to store collected cells, and p ...[more]