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The pathophysiology and pharmacology of hepcidin.

ABSTRACT: Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias. Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical illness, some cancers, and chronic kidney disease. Multiple agents targeting hepcidin and its regulators are under development as novel therapeutics for iron disorders. This review summarizes hepcidin biology and discusses the current landscape for hepcidin-targeting therapeutic strategies.

SUBMITTER: Ruchala P 

PROVIDER: S-EPMC3978192 | biostudies-other | 2014 Mar

REPOSITORIES: biostudies-other

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The pathophysiology and pharmacology of hepcidin.

Ruchala Piotr P   Nemeth Elizabeta E  

Trends in pharmacological sciences 20140217 3

Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias. Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical illness, some cancers, and chronic kidney disease. Multiple agents targeting hepcidin and its regulators are under development as novel therapeutics  ...[more]

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