Ontology highlight
ABSTRACT:
SUBMITTER: Ruchala P
PROVIDER: S-EPMC3978192 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Trends in pharmacological sciences 20140217 3
Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias. Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical illness, some cancers, and chronic kidney disease. Multiple agents targeting hepcidin and its regulators are under development as novel therapeutics ...[more]