Ontology highlight
ABSTRACT:
SUBMITTER: Gupta A
PROVIDER: S-EPMC3982132 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Gupta Anurag A Wang Shouyan S Marko Aimee A Joshi Penny P Ethirajan Manivannan M Chen Yihui Y Yao Rutao R Sajjad Munawwar M Kopelman Raoul R Pandey Ravindra K RK
Theranostics 20140316 6
In this report we demonstrate the outstanding advantages of multifunctional nanoplatforms for cancer-imaging and therapy. The non-toxic polyacrylamide (PAA) nanoparticles (size:18-25 nm) formulation drastically changed the pharmacokinetic profile of the ¹²⁴I- labeled chlorophyll-a derivative (formulated in 10% ethanol in PBS) with a remarkable enhancement in tumor uptake, and significantly reduced uptake in spleen and liver. Among the various nanoformulations investigated, the ¹²⁴I- labeled phot ...[more]