Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men.
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ABSTRACT:
SUBMITTER: Joensen UN
PROVIDER: S-EPMC3984221 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
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Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men.
Joensen Ulla Nordström UN Jørgensen Niels N Meldgaard Michael M Frederiksen Hanne H Andersson Anna-Maria AM Menné Torkil T Johansen Jeanne Duus JD Carlsen Berit Christina BC Stender Steen S Szecsi Pal Bela PB Skakkebæk Niels Erik NE Rajpert-De Meyts Ewa E Thyssen Jacob P JP
Environmental health perspectives 20140103 4
<h4>Background</h4>Filaggrin is an epidermal protein that is crucial for skin barrier function. Up to 10% of Europeans and 5% of Asians carry at least one null allele in the filaggrin gene (FLG). Reduced expression of filaggrin in carriers of the null allele is associated with facilitated transfer of allergens across the epidermis. We hypothesized that these individuals may have increased transdermal uptake of endocrine disruptors, including phthalates.<h4>Objectives</h4>We investigated urinary ...[more]
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