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Palladium-catalyzed ?-arylation of benzylic phosphonates.

ABSTRACT: A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)2/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).

SUBMITTER: Montel S 

PROVIDER: S-EPMC3993846 | biostudies-other | 2014 Mar

REPOSITORIES: biostudies-other

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Palladium-catalyzed α-arylation of benzylic phosphonates.

Montel Sonia S   Raffier Ludovic L   He Yuying Y   Walsh Patrick J PJ  

Organic letters 20140212 5

A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)2/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%). ...[more]