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Iron-catalyzed arylation of heterocycles via directed C-H bond activation.

ABSTRACT: The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls.

SUBMITTER: Sirois JJ

PROVIDER: S-EPMC3993849 | biostudies-other | 2014 Feb

REPOSITORIES: biostudies-other

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Iron-catalyzed arylation of heterocycles via directed C-H bond activation.

Sirois John J JJ Davis Riley R DeBoef Brenton B

Organic letters 20140122 3

The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls. ...[more]

PMID: 24450989

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