Unknown

Dataset Information

0

Iron-catalyzed arylation of heterocycles via directed C-H bond activation.

ABSTRACT: The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls.

SUBMITTER: Sirois JJ 

PROVIDER: S-EPMC3993849 | biostudies-other | 2014 Feb

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Iron-catalyzed arylation of heterocycles via directed C-H bond activation.

Sirois John J JJ   Davis Riley R   DeBoef Brenton B  

Organic letters 20140122 3

The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls. ...[more]

Similar Datasets

Unknown Rh(I)-catalyzed arylation of heterocycles via C-H bond activation: expanded scope through mechanistic insight.
| S-EPMC2693036 | biostudies-literature
Unknown Thioketone-directed rhodium(I) catalyzed enantioselective C-H bond arylation of ferrocenes.
| S-EPMC6744407 | biostudies-other
Unknown Efficient Pd-catalyzed coupling of tautomerizable heterocycles with terminal alkynes via C-OH bond activation using PyBrOP.
| S-EPMC2873160 | biostudies-literature
Unknown Palladium-Catalyzed Pyrazole-Directed sp3 C-H Bond Arylation for the Synthesis of ?-Phenethylamines.
| S-EPMC5480374 | biostudies-literature
Unknown Rhodium(III)-catalyzed arylation of Boc-imines via C-H bond functionalization.
| S-EPMC3045530 | biostudies-literature
Unknown Pd(II)-catalyzed ortho arylation of 2-arylbenzothiazoles with aryl iodides via benzothiazole-directed C-H activation.
| S-EPMC3363328 | biostudies-literature
Unknown Palladium-Catalyzed Directed C(sp3)-H Arylation of Saturated Heterocycles at C-3 Using a Concise Optimization Approach.
| S-EPMC4736452 | biostudies-literature
Unknown Pyridylidene ligand facilitates gold-catalyzed oxidative C-H arylation of heterocycles.
| S-EPMC4734412 | biostudies-other
Unknown Pd-Catalyzed Directed Thiocyanation Reaction by C-H Bond Activation.
| S-EPMC7756308 | biostudies-literature
Unknown Steric modulation of chiral biaryl diamines via Pd-catalyzed directed C-H arylation.
| S-EPMC2726659 | biostudies-literature