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Direct access to functionalized azepanes by cross-coupling with ?-halo eneformamides.

ABSTRACT: The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of ?-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained.

SUBMITTER: Beng TK

PROVIDER: S-EPMC3993866 | biostudies-other | 2014 Feb

REPOSITORIES: biostudies-other

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Direct access to functionalized azepanes by cross-coupling with α-halo eneformamides.

Beng Timothy K TK Wilkerson-Hill Sidney M SM Sarpong Richmond R

Organic letters 20140123 3

The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained. ...[more]

PMID: 24456197

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