Metabolomic analysis of siderophore cheater mutants reveals metabolic costs of expression in uropathogenic Escherichia coli.
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ABSTRACT:
SUBMITTER: Lv H
PROVIDER: S-EPMC3993901 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
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Metabolomic analysis of siderophore cheater mutants reveals metabolic costs of expression in uropathogenic Escherichia coli.
Lv Haitao H Hung Chia S CS Henderson Jeffrey P JP
Journal of proteome research 20140207 3
Bacterial siderophores are a group of chemically diverse, virulence-associated secondary metabolites whose expression exerts metabolic costs. A combined bacterial genetic and metabolomic approach revealed differential metabolomic impacts associated with biosynthesis of different siderophore structural families. Despite myriad genetic differences, the metabolome of a cheater mutant lacking a single set of siderophore biosynthetic genes more closely approximate that of a non-pathogenic K12 strain ...[more]
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