Ontology highlight
ABSTRACT:
SUBMITTER: Trower MK
PROVIDER: S-EPMC39943 | biostudies-other | 1996 Feb
REPOSITORIES: biostudies-other
Trower M K MK Orton S M SM Purvis I J IJ Sanseau P P Riley J J Christodoulou C C Burt D D See C G CG Elgar G G Sherrington R R Rogaev E I EI St George-Hyslop P P Brenner S S Dykes C W CW
Proceedings of the National Academy of Sciences of the United States of America 19960201 4
The genome of the pufferfish (Fugu rubripes) (400 Mb) is approximately 7.5 times smaller than the human genome, but it has a similar gene repertoire to that of man. If regions of the two genomes exhibited conservation of gene order (i.e., were syntenic), it should be possible to reduce dramatically the effort required for identification of candidate genes in human disease loci by sequencing syntenic regions of the compact Fugu genome. We have demonstrated that three genes (dihydrolipoamide succi ...[more]