TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells.
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ABSTRACT:
SUBMITTER: Li BH
PROVIDER: S-EPMC4001301 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Publications
TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells.
Li B-H BH Yin Y-W YW Liu Y Y Pi Y Y Guo L L Cao X-J XJ Gao C-Y CY Zhang L-L LL Li J-C JC
Cell death & disease 20140417
Vascular smooth muscle cells (VSMCs) are an important origin of foam cells besides macrophages. The mechanisms underlying VSMC foam cell formation are relatively little known. Activation of transient receptor potential vanilloid subfamily 1 (TRPV1) and autophagy have a potential role in regulating foam cell formation. Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the ...[more]
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