Ontology highlight
ABSTRACT:
SUBMITTER: Saxena V
PROVIDER: S-EPMC4006997 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
Saxena Vijay V Shivakumar Pranavkumar P Sabla Gregg G Mourya Reena R Chougnet Claire C Bezerra Jorge A JA
Science translational medicine 20110901 102
Biliary atresia is the most common cholangiopathy of childhood. During infancy, an idiopathic activation of the neonatal immune system targets the biliary epithelium, obstructs bile ducts, and disrupts the anatomic continuity between the liver and the intestine. Here, we use a model of virus-induced biliary atresia in newborn mice to trace the initiating pathogenic disease mechanisms to resident plasmacytoid (pDCs) and conventional (cDCs) dendritic cells. We found pDCs to be the most abundant DC ...[more]