Ontology highlight
ABSTRACT:
SUBMITTER: Karuppagounder SS
PROVIDER: S-EPMC4007078 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Karuppagounder Senthilkumar S SS Brahmachari Saurav S Lee Yunjong Y Dawson Valina L VL Dawson Ted M TM Ko Han Seok HS
Scientific reports 20140502
c-Abl is activated in the brain of Parkinson's disease (PD) patients and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice where it inhibits parkin through tyrosine phosphorylation leading to the accumulation of parkin substrates, and neuronal cell death. In the present study, we evaluated the in vivo efficacy of nilotinib, a brain penetrant c-Abl inhibitor, in the acute MPTP-induced model of PD. Our results show that administration of nilotinib reduces c-Abl activation and ...[more]