Ontology highlight
ABSTRACT:
SUBMITTER: Budzik B
PROVIDER: S-EPMC4007837 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20100608 6
Virtual screening of the corporate compound collection yielded compound 1 as a subtype selective muscarinic M1 receptor agonist hit. Initial optimization of the N-capping group of the central piperidine ring resulted in compounds 2 and 3 with significantly improved potency and selectivity. Subsequent optimization of substituents on the phenyl ring of the benzimidazolone moiety led to the discovery of novel muscarinic M1 receptor agonists 4 and 5 with excellent potency, general and subtype select ...[more]