Ontology highlight
ABSTRACT:
SUBMITTER: Navratilova I
PROVIDER: S-EPMC4007845 | biostudies-other | 2010 Apr
REPOSITORIES: biostudies-other
Navratilova Iva I Hopkins Andrew L AL
ACS medicinal chemistry letters 20100204 1
Fragment-based drug discovery is a validated approach for the discovery of drug candidates. However, the weak affinity of fragment compounds requires highly sensitive biophysical techniques, such as nuclear magnetic resonance (NMR) or X-ray crystallography, to identify hits. Thus the advantages of screening small fragment libraries are partly offset by the high cost of biophysical analyses. Here we present a method for biosensor-based fragment screening using surface plasmon resonance (SPR). In ...[more]