Ontology highlight
ABSTRACT:
SUBMITTER: Ding D
PROVIDER: S-EPMC4007846 | biostudies-other | 2010 Jul
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20100406 4
We report the discovery of benzoxaborole antitrypanosomal agents and their structure-activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC50 values as low as 0.02 μg/mL and in vivo efficacy in acute murine infection models against Tryapnosoma brucei. ...[more]