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Cholesterol's aliphatic side chain modulates membrane properties.

ABSTRACT: The influence of cholesterol's alkyl side chain on membrane properties was studied using a series of synthetic cholesterol derivatives without a side chain or with a branched side chain consisting of 5 to 14 carbon atoms. Cholesterol's side chain is crucial for all membrane properties investigated and therefore essential for the membrane properties of eukaryotic cells.

SUBMITTER: Scheidt HA 

PROVIDER: S-EPMC4011182 | biostudies-other | 2013 Dec

REPOSITORIES: biostudies-other

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Cholesterol's aliphatic side chain modulates membrane properties.

Scheidt Holger A HA   Meyer Thomas T   Nikolaus Jörg J   Baek Dong Jae DJ   Haralampiev Ivan I   Thomas Lars L   Bittman Robert R   Müller Peter P   Herrmann Andreas A   Huster Daniel D  

Angewandte Chemie (International ed. in English) 20131125 49

The influence of cholesterol's alkyl side chain on membrane properties was studied using a series of synthetic cholesterol derivatives without a side chain or with a branched side chain consisting of 5 to 14 carbon atoms. Cholesterol's side chain is crucial for all membrane properties investigated and therefore essential for the membrane properties of eukaryotic cells. ...[more]