Ontology highlight
ABSTRACT:
SUBMITTER: Cho A
PROVIDER: S-EPMC4011666 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Cho Ahryon A Tang Yitai Y Davila Jonathan J Deng Suhua S Chen Lei L Miller Erik E Wernig Marius M Graef Isabella A IA
Neuron 20140401 1
Development of the nervous system begins with neural induction, which is controlled by complex signaling networks functioning in concert with one another. Fine-tuning of the bone morphogenetic protein (BMP) pathway is essential for neural induction in the developing embryo. However, the molecular mechanisms by which cells integrate the signaling pathways that contribute to neural induction have remained unclear. We find that neural induction is dependent on the Ca(2+)-activated phosphatase calci ...[more]