Ontology highlight
ABSTRACT:
SUBMITTER: Sodt AJ
PROVIDER: S-EPMC4017297 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Sodt Alexander J AJ Pastor Richard W RW
Biophysical journal 20140501 9
Molecular dynamics simulations of an amphipathic helix embedded in a lipid bilayer indicate that it will induce substantial positive curvature (e.g., a tube of diameter 20 nm at 16% surface coverage). The induction is twice that of a continuum model prediction that only considers the shape of the inclusion. The discrepancy is explained in terms of the additional presence of specific interactions described only by the molecular model. The conclusion that molecular shape alone is insufficient to q ...[more]