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Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study.

ABSTRACT: Effects of alcohol consumption on health and disease are complex and involve a number of cellular and metabolic processes.We examined the association between alcohol consumption habits and metabolomic profiles.We conducted a cross-sectional study to explore the association of alcohol consumption habits measured by using a questionnaire with serum metabolites measured by using untargeted mass spectrometry in 1977 African Americans from the Jackson field center in the Atherosclerosis Risk in Communities Study. The whole sample was split into a discovery set (n = 1500) and a replication set (n = 477). Alcohol consumption habits were treated as an ordinal variable, with nondrinkers as the reference group and quartiles of current drinkers as ordinal groups with higher values. For each metabolite, a linear regression was conducted to estimate its relation with alcohol consumption habits separately in both sets. A modified Bonferroni procedure was used in the discovery set to adjust the significance threshold (P < 1.9 × 10??).In 356 named metabolites, 39 metabolites were significantly associated with alcohol consumption habits in both discovery and replication sets. In general, alcohol consumption was associated with higher levels of most metabolites such as those in amino acid and lipid pathways and with lower levels of ?-glutamyl dipeptides. Three pathways, 2-hydroxybutyrate-related metabolites, ?-glutamyl dipeptides, and lysophosphatidylcholines, which are considered to be involved in inflammation and oxidation, were associated with incident cardiovascular diseases.To our knowledge, this is the largest metabolomic study thus far conducted in nonwhites. Metabolomic biomarkers of alcohol consumption were identified and replicated. The results lend new insight into potential mediating effects between alcohol consumption and future health and disease.

SUBMITTER: Zheng Y

PROVIDER: S-EPMC4021786 | biostudies-other | 2014 Jun

REPOSITORIES: biostudies-other

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Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study.

Zheng Yan Y Yu Bing B Alexander Danny D Steffen Lyn M LM Nettleton Jennifer A JA Boerwinkle Eric E

The American journal of clinical nutrition 20140423 6

<h4>Background</h4>Effects of alcohol consumption on health and disease are complex and involve a number of cellular and metabolic processes.<h4>Objective</h4>We examined the association between alcohol consumption habits and metabolomic profiles.<h4>Design</h4>We conducted a cross-sectional study to explore the association of alcohol consumption habits measured by using a questionnaire with serum metabolites measured by using untargeted mass spectrometry in 1977 African Americans from the Jacks ...[more]

PMID: 24760976

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Project description:BackgroundPublic health recommendations on the benefits and harms of moderate alcohol intake require a thorough and unbiased understanding of all potential effects of various levels and patterns of alcohol consumption. We seek to evaluate the associations between patterns of current and past alcohol consumption with hospitalizations and mortality.MethodsData came from a prospective cohort of 12,327 adults (56% women, 78% white, mean age 60 years) participating in the Atherosclerosis Risk in Communities study visit 3 (1993 to 1995). Current and past alcohol consumption was based on self-report. Hospitalizations and mortality were ascertained through December 31, 2017. Negative binomial and Cox proportional hazards regressions were used.Results24.8% of the study population reported never drinking, 48.3% reported currently drinking without a history of heavy drinking, 4.2% reported currently drinking with a history of heavy drinking, 19.2% reported being former drinkers without a history of heavy drinking, and 3.4% reported being former drinkers with a history of heavy drinking. Compared to those who reported drinking ≤1 to 7 drinks/wk, never drinkers (incident rate ratio [IRR]: 1.21 (95% confidence interval 1.13, 1.29) and former drinkers with (IRR: 1.43 [1.26, 1.63]) or without (IRR: 1.21 [1.13, 1.30]) a history of heavy drinking had a positive association with all-cause hospitalization (p < 0.001). Those who reported drinking ≤1 to 7 drinks/wk had the lowest all-cause mortality rate (19.2 per 1,000 person-years [18.4, 20.1]) and former drinkers with a history of heavy drinking had the highest (43.7 per 1,000 person-years [39.0, 49.1]).ConclusionsThe positive associations with hospitalization and mortality were stronger among never and former drinkers compared to those who consume ≤1 to 7 drinks/wk. Former drinkers with a history of heavy drinking had a stronger positive association with adverse health outcomes than former drinkers without a history of heavy drinking, highlighting the impact of this pattern of alcohol consumption.

Dataset Information

Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study.

Publications

Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study.

Similar Datasets

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