Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Gomez P
PROVIDER: S-EPMC4022209 | biostudies-other | 2014
REPOSITORIES: biostudies-other
González-Gómez Pilar P Anselmo Nilson Praia NP Mira Helena H
BioMed research international 20140428
Astrocytic glioma is the most common brain tumor. The glioma initiating cell (GIC) fraction of the tumor is considered as highly chemoresistant, suggesting that GICs are responsible for glioma relapse. A potential treatment for glioma is to induce differentiation of GICs to a more benign and/or druggable cell type. Given BMPs are among the most potent inducers of GIC differentiation, they have been considered as noncytotoxic therapeutic compounds that may be of use to prevent growth and recurren ...[more]