Ontology highlight
ABSTRACT:
SUBMITTER: Wang HN
PROVIDER: S-EPMC4022285 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
Wang Hsin-Neng HN Fales Andrew M AM Zaas Aimee K AK Woods Christopher W CW Burke Thomas T Ginsburg Geoffrey S GS Vo-Dinh Tuan T
Analytica chimica acta 20130520
In this paper, we describe a surface-enhanced Raman scattering (SERS)-based detection approach, referred to as "molecular sentinel" (MS) plasmonic nanoprobes, to detect an RNA target related to viral infection. The MS method is essentially a label-free technique incorporating the SERS effect modulation scheme associated with silver nanoparticles and Raman dye-labeled DNA hairpin probes. Hybridization with target sequences opens the hairpin and spatially separates the Raman label from the silver ...[more]