Ontology highlight
ABSTRACT:
SUBMITTER: Maity G
PROVIDER: S-EPMC4023131 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Maity Gargi G Mehta Smita S Haque Inamul I Dhar Kakali K Sarkar Sandipto S Banerjee Sushanta K SK Banerjee Snigdha S
Scientific reports 20140516
The complex signaling networks between cancer cells and adjacent endothelial cells make it challenging to unravel how cancer cells send extracellular messages to promote aberrant vascularization or tumor angiogenesis. Here, in vitro and in vivo models show that pancreatic cancer cell generated unique microenvironments can underlie endothelial cell migration and tumor angiogenesis. Mechanistically, we find that pancreatic cancer cell secreted CCN1/Cyr61 matricellular protein rewires the microenvi ...[more]