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Impaired fear memory specificity associated with deficient endocannabinoid-dependent long-term plasticity.

ABSTRACT: In addition to its central role in learning and memory, N-methyl D-aspartate receptor (NMDAR)-dependent signaling regulates central glutamatergic synapse maturation and has been implicated in schizophrenia. We have transiently induced NMDAR hypofunction in infant mice during postnatal days 7-11, followed by testing fear memory specificity and presynaptic plasticity in the prefrontal cortex (PFC) in adult mice. We show that transient NMDAR hypofunction during early brain development, coinciding with the maturation of cortical plasticity results in a loss of an endocannabinoid (eCB)-mediated form of long-term depression (eCB-LTD) at adult central glutamatergic synapses, while another form of presynaptic long-term depression mediated by the metabotropic glutamate receptor 2/3 (mGluR2/3-LTD) remains intact. Mice with this selective impairment of presynaptic plasticity also showed deficits in fear memory specificity. The observed deficit in cortical presynaptic plasticity may represent a neural maladaptation contributing to network instability and abnormal cognitive functioning.

SUBMITTER: Lovelace JW 

PROVIDER: S-EPMC4023141 | biostudies-other | 2014 Jun

REPOSITORIES: biostudies-other

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Impaired fear memory specificity associated with deficient endocannabinoid-dependent long-term plasticity.

Lovelace Jonathan W JW   Vieira Philip A PA   Corches Alex A   Mackie Ken K   Korzus Edward E  

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20140124 7

In addition to its central role in learning and memory, N-methyl D-aspartate receptor (NMDAR)-dependent signaling regulates central glutamatergic synapse maturation and has been implicated in schizophrenia. We have transiently induced NMDAR hypofunction in infant mice during postnatal days 7-11, followed by testing fear memory specificity and presynaptic plasticity in the prefrontal cortex (PFC) in adult mice. We show that transient NMDAR hypofunction during early brain development, coinciding w  ...[more]

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