Ontology highlight
ABSTRACT:
SUBMITTER: Hollands K
PROVIDER: S-EPMC4024889 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Hollands Kerry K Sevostiyanova Anastasia A Groisman Eduardo A EA
Proceedings of the National Academy of Sciences of the United States of America 20140428 19
Up to half of all transcription termination events in bacteria rely on the RNA-dependent helicase Rho. However, the nucleic acid sequences that promote Rho-dependent termination remain poorly characterized. Defining the molecular determinants that confer Rho-dependent termination is especially important for understanding how such terminators can be regulated in response to specific signals. Here, we identify an extraordinarily long-lived pause at the site where Rho terminates transcription in th ...[more]