Ontology highlight
ABSTRACT:
SUBMITTER: Chang TY
PROVIDER: S-EPMC4025792 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20121030 12
Through the syntheses of its C-1 desvinyl, C-7 methylene, C-7 exocyclic ethylidene, and various C-3 phenylmethyl analogues, the structure-activity relationship of antimitotic ottelione A (4) against tubulin and various cancer cells was established. The results indicated that compound 4 was a colchicine-competitive inhibitor and that the C-1 vinyl group is unnecessary for its potency, whereas the C-7 exocyclic double bond is essential, possibly because of its irreversible interaction with tubulin ...[more]