Ontology highlight
ABSTRACT:
SUBMITTER: Villalta-Romero F
PROVIDER: S-EPMC4025828 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Villalta-Romero Fabián F Gortat Anna A Herrera Andrés E AE Arguedas Rebeca R Quesada Javier J de Melo Robson Lopes RL Calvete Juan J JJ Montero Mavis M Murillo Renato R Rucavado Alexandra A Gutiérrez José María JM Pérez-Payá Enrique E
ACS medicinal chemistry letters 20120614 7
The majority of snakebite envenomations in Central America are caused by the viperid species Bothrops asper, whose venom contains a high proportion of zinc-dependent metalloproteinases that play a relevant role in the pathogenesis of hemorrhage characteristic of these envenomations. Broad metalloproteinase inhibitors, such as the peptidomimetic hydroxamate Batimastat, have been shown to inhibit snake venom metalloproteinases (SVMP). However, the difficulty in having open public access to Batimas ...[more]