Ontology highlight
ABSTRACT:
SUBMITTER: Keith JM
PROVIDER: S-EPMC4025847 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20120822 10
A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey. The elevation of the levels of these lipids in the plasma of monkeys suggests that FAAH-2 may not play a significant role in reg ...[more]