Ontology highlight
ABSTRACT:
SUBMITTER: Torres E
PROVIDER: S-EPMC4025864 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Torres Eva E Fernández Roser R Miquet Stéphanie S Font-Bardia Mercè M Vanderlinden Evelien E Naesens Lieve L Vázquez Santiago S
ACS medicinal chemistry letters 20121022 12
The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells. ...[more]