Ontology highlight
ABSTRACT:
SUBMITTER: Dechassa ML
PROVIDER: S-EPMC4027189 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Nucleic acids research 20140312 9
The assembly of centromeric nucleosomes is mediated by histone variant-specific chaperones. In budding yeast, the centromere-specific histone H3 variant is Cse4, and the histone chaperone Scm3 functions as a Cse4-specific nucleosome assembly factor. Here, we show that Scm3 exhibits specificity for Cse4-H4, but also interacts with major-type H3-H4 and H2A-H2B. Previously published structures of the Scm3 histone complex demonstrate that Scm3 binds only one copy of Cse4-H4. Consistent with this, we ...[more]