Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4027506 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Li Xianlin X Tu Zhenchao Z Li Hua H Liu Chunping C Li Zheng Z Sun Qiao Q Yao Yiwu Y Liu Jinsong J Jiang Sheng S
ACS medicinal chemistry letters 20121205 1
We report the design, synthesis, and biological evaluation of a new series of largazole analogues in which a 4-methylthiazoline moiety was replaced with a triazole and tetrazole ring, respectively. Compound 7 bearing a tetrazole ring was identified to show much better selectivity for HDAC1 over HDAC9 than largazole (10-fold). This work could serve as a foundation for further exploration of selective HDAC inhibitors using a largazole molecular scaffold. ...[more]