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Improving the plausibility of success with inefficient metrics.


ABSTRACT: To increase the probability of success in drug discovery, the concept of drug-like properties was introduced. Efficiency metrics that normalize potency against these properties could help reach drug-like space more efficiently. Potential reasons for the inefficient use of metrics and suboptimal decision making are discussed.

SUBMITTER: Shultz MD 

PROVIDER: S-EPMC4027587 | biostudies-other | 2014 Jan

REPOSITORIES: biostudies-other

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