Ontology highlight
ABSTRACT:
SUBMITTER: Mrozek-Wilczkiewicz A
PROVIDER: S-EPMC4027794 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Mrozek-Wilczkiewicz Anna A Serda Maciej M Musiol Robert R Malecki Grzegorz G Szurko Agnieszka A Muchowicz Angelika A Golab Jakub J Ratuszna Alicja A Polanski Jaroslaw J
ACS medicinal chemistry letters 20140123 4
In photodynamic therapy (PDT), a noninvasive anticancer treatment, visible light, is used as a magic bullet selectively destroying cancer cells by a photosensitizer that is nontoxic in the dark. Protoporphyrin IX (PpIX) is a natural photosensitizer synthesized in the cell, which is also a chelating agent that if bonded to Fe(2+) forms heme, a central component of hemoglobin. Therefore, xenobiotic iron chelators can disturb iron homeostasis, increasing the accumulation of PpIX, obstructing the la ...[more]